DRUG DISCOVERY WORKFLOWS

Drug discovery

An evidence-driven path across target validation, screening, efficacy assessment and research support.

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WORKFLOW MAP

From sample to evidence

01

Target validation

Combine genetics, protein interaction, binding and cellular mechanism evidence to assess target feasibility.

  1. Disease-association evidence
  2. Expression and localization
  3. Direct binding or occupancy
  4. Cellular mechanism

RisksAssociation is not causation, model mismatch and missing independent validation.

QCControls, orthogonal methods, dose relationship and independent models.

Recommended products

解脲脲原体（UU）核酸检测试剂盒（PCR荧光探针法） BFRT111M 沙眼衣原体（CT）核酸检测试剂盒（PCR荧光探针法） BFRT112M 淋球菌（NG）核酸检测试剂盒（PCR荧光探针法） BFRT113M 乙型肝炎病毒（HBV）核酸定量检测试剂盒（PCR荧光探针法） BFRT114M 乙型肝炎病毒（HBV）核酸定量检测试剂盒（PCR荧光探针法） BFRT114D6 丙型肝炎病毒（HCV）核酸定量检测试剂盒（PCR荧光探针法） BFRT115M 丙型肝炎病毒（HCV）核酸定量检测试剂盒（PCR荧光探针法） BFRT115D6 人类ALDH2基因多态性核酸检测试剂盒（PCR荧光探针法） BFRT116M 人类CYP2C9基因多态性核酸检测试剂盒（PCR荧光探针法） BFRT117M
Research diagnostic reagents Configure this workflow

02

Compound screening

Use high-throughput, phenotypic or virtual screens, then cascade assays to remove false positives.

  1. Plan library and plate layout
  2. Run primary screen
  3. Confirm and dose-response
  4. Check binding and selectivity

RisksPlate effects, assay interference, false positives and weak repeat hits.

QCZ' factor, plate drift, hit rate, repeatability and orthogonal readouts.

Recommended products

解脲脲原体（UU）核酸检测试剂盒（PCR荧光探针法） BFRT111M 96孔2.2mL深孔板 BFMH01A 沙眼衣原体（CT）核酸检测试剂盒（PCR荧光探针法） BFRT112M 6孔2.2ml深孔板 BFMH01B 淋球菌（NG）核酸检测试剂盒（PCR荧光探针法） BFRT113M 磁棒套（八联） BFMH02 乙型肝炎病毒（HBV）核酸定量检测试剂盒（PCR荧光探针法） BFRT114M 磁棒套（八联） BFMH02B 乙型肝炎病毒（HBV）核酸定量检测试剂盒（PCR荧光探针法） BFRT114D6 磁棒套（八联） BFMH02T 丙型肝炎病毒（HCV）核酸定量检测试剂盒（PCR荧光探针法） BFRT115M 96孔2.2mL深孔板 BFMH07 丙型肝炎病毒（HCV）核酸定量检测试剂盒（PCR荧光探针法） BFRT115D6 磁棒套（96联） BFMH08 人类ALDH2基因多态性核酸检测试剂盒（PCR荧光探针法） BFRT116M 磁棒套（96联） BFMH08E 人类CYP2C9基因多态性核酸检测试剂盒（PCR荧光探针法） BFRT117M 单样本单支底座固定套 BFMH10 10ul吸头 BFMH12 200ul吸头 BFMH13 1000ul吸头 BFMH14 100ul吸头 BFMH21 八联PCR管 BFMH15 八联PCR管 BFMH15B 24孔15ml深孔板 BFMH16 磁棒套（15ml） BFMH17 24孔10ml深孔板 BFMH18 磁棒套（10ml） BFMH19 研磨管 BFMH20-1 研磨管 BFMH20-2 研磨管 BFMH20-3 研磨管 BFMH20-4
Supporting consumablesResearch diagnostic reagents Configure this workflow

03

Efficacy assessment

Evaluate potency, selectivity, mechanism and resistance risk in cell, organoid or animal models.

  1. Define model and endpoint
  2. Design dose and time
  3. Read phenotype and mechanism
  4. Analyze effect and replicates

RisksModel extrapolation, insufficient exposure, toxicity confounding and low power.

QCEC50/IC50, exposure, viability, mechanism markers and independent repeats.

Recommended products

凝胶成像系统 BFGI-500 解脲脲原体（UU）核酸检测试剂盒（PCR荧光探针法） BFRT111M 沙眼衣原体（CT）核酸检测试剂盒（PCR荧光探针法） BFRT112M 淋球菌（NG）核酸检测试剂盒（PCR荧光探针法） BFRT113M 乙型肝炎病毒（HBV）核酸定量检测试剂盒（PCR荧光探针法） BFRT114M 乙型肝炎病毒（HBV）核酸定量检测试剂盒（PCR荧光探针法） BFRT114D6 丙型肝炎病毒（HCV）核酸定量检测试剂盒（PCR荧光探针法） BFRT115M 丙型肝炎病毒（HCV）核酸定量检测试剂盒（PCR荧光探针法） BFRT115D6 人类ALDH2基因多态性核酸检测试剂盒（PCR荧光探针法） BFRT116M 人类CYP2C9基因多态性核酸检测试剂盒（PCR荧光探针法） BFRT117M 凝胶成像系统 BFGI-600
Gel imaging systemsResearch diagnostic reagents Configure this workflow

04

Research support

Connect data analysis, sample management, method development and review for continuous candidate progression.

  1. Register data and samples
  2. Lock methods and parameters
  3. Review results
  4. Design the next decision cycle

RisksVersion confusion, irreproducibility and unclear decision boundaries.

QCData lineage, versions, audit trails, review sign-off and decision records.

Recommended products

96孔2.2mL深孔板 BFMH01A 6孔2.2ml深孔板 BFMH01B 磁棒套（八联） BFMH02 磁棒套（八联） BFMH02B 磁棒套（八联） BFMH02T 96孔2.2mL深孔板 BFMH07 磁棒套（96联） BFMH08 磁棒套（96联） BFMH08E 单样本单支底座固定套 BFMH10 10ul吸头 BFMH12 200ul吸头 BFMH13 1000ul吸头 BFMH14 100ul吸头 BFMH21 八联PCR管 BFMH15 八联PCR管 BFMH15B 24孔15ml深孔板 BFMH16 磁棒套（15ml） BFMH17 24孔10ml深孔板 BFMH18 磁棒套（10ml） BFMH19 研磨管 BFMH20-1 研磨管 BFMH20-2 研磨管 BFMH20-3 研磨管 BFMH20-4
Supporting consumables Configure this workflow

RESEARCH UPDATES

Recent research and workflow evidence