Efficacy assessment · Research update
Systems-level machine learning for therapeutic target discovery
Multi-omic and large-scale drug-sensitivity data identify candidate targets followed by cell-line efficacy evaluation.
npj Drug Discovery
Systems-level models combine disease data, drug responses and cell-line screens to propose testable targets and repurposing candidates.
Target validation should include independent cell models, dose-response curves, mechanistic readouts, resistance backgrounds and positive controls.
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